Examining the positive effects of sleep deprivation leads to new information about how we sleep.

By Regina Patrick, RPSGT

Studies well document the negative effects of sleep deprivation (decreased vigilance, impaired decision-making, reduced concentration, irritability, sleepiness, increased fatigue, and difficulty thinking clearly). Interestingly, sleep deprivation can have positive effects such as tireless stamina, enhanced creativity, heightened awareness, and a cheerful mood. Investigations into its more positive effects are giving scientists new perceptions about sleep deprivation.

Scientists have found that everyone is not affected to the same degree by sleep deprivation. Some people after an episode have a natural resistance to its negative effects. For example, in 2002, van Dongen and associates1 presented a study that submitted subjects to two sleep-deprivation periods with each lasting 36 hours. (The sleep-deprivation periods were separated by a 2- to 4-week interval.) They found that the subjects who easily fatigued after sleep deprivation had a similar degree of fatigue after both test periods and the subjects who were resistant to fatigue after sleep deprivation were equally resistant for both of the test periods. An earlier study in 1980 by Morgan and associates1 had similar results. The researchers subjected volunteers to four periods of sleep deprivation with each period lasting 44 hours. (The sleep deprivation periods were separated by a 1-week interval.) They found that volunteers had the same degree of fatigue-resistance or fatigue-vulnerability for each of the four test periods.

Brain imaging1 shows that the brains of fatigue-resistant and fatigue-vulnerable people are different. A fatigue-resistant person’s brain has a higher degree of activity—even before sleep deprivation—than the brain of a fatigue-vulnerable person. This difference is now being investigated by military scientists. Potentially, using fatigue-resistant individuals for tasks involving long periods of little sleep (long reconnaissance missions) may avoid mistakes caused by inattentiveness and fatigue that could occur with a fatigue-vulnerable individual.

Polyphasic Sleep

Since studies consistently show the detrimental effects of sleep deprivation on performance and alertness, sleep scientists often advise against a person’s becoming sleep-deprived; however, one technique of severe sleep restriction called polyphasic sleep appears to maintain one’s level of performance and alertness. Polyphasic sleep involves taking short naps (about 20 to 30 minutes) every 4 hours. On this schedule, a person will sleep 2 to 3 total hours in a 24-hour period. A National Aeronautics and Space Administration (NASA) study2,3 found that subjects who restricted their sleep to 30 minutes every 4 hours (3 total hours of sleep in a 24-hour period) were more alert and performed better than when they restricted their sleep to an uninterrupted 3-hour period (within 24 hours).

This paradoxical aspect of polyphasic sleep may lie in its effect on circadian rhythms. Normally, sleep deprivation disrupts the circadian rhythms of various physiological processes such as melatonin production and cortisol production. Frequent naps in a polyphasic sleep schedule seem to allow these rhythms to be maintained despite the severe sleep restriction. Scientists suspect that one’s alertness and productivity are maintained since circadian rhythms are maintained.

Some people naturally undergo periods of polyphasic sleep. During this time, they note increased productivity and creativity. For example, artists Leonardo Da Vinci reportedly slept for 15 minutes every 4 hours and Michelangelo reportedly slept only 4 hours per night; inventor Thomas Edison slept 3 to 4 hours per night; and politician Winston Churchill had periods throughout his life in which he would sleep 6 hours at night and take a short nap during the day. All of these people had great creativity and/or productivity despite the severe sleep restriction.4

Until the advent of brain imaging, scientists hypothesized that sleep deprivation causes decreased activation of certain areas in the brain, which in turn results in its negative consequences. Validating this hypothesis, some brain imaging studies5 show that a sleep-deprived brain has decreased activity in the prefrontal cortex. This area plays a role in vigilance, attention span, planning, judgment, verbal learning, and some aspects of memory.

Brain Imaging Study

A 2000 University of California at San Diego study has found that the brain can compensate for sleep deprivation. In the study, Drummond and associates5 took a baseline functional magnetic resonance imaging (fMRI) scan of rested subjects while the subjects performed verbal memorization tasks. The researchers noted increased activation in the left prefrontal cortex, the left premotor area (located on the frontal lobe), and the speech center on the left temporal lobe. The subjects then underwent a 35-hour sleep deprivation period. Afterward, the researchers took a second fMRI scan as the now sleep-deprived subjects repeated the verbal memorization tasks. Since sleep deprivation usually reduces activation of the prefrontal cortex but verbal tasks increase activation, the researchers expected the area to be activated but at a lower-than-normal level. Instead, the second scan revealed that the prefrontal and parietal lobes were more activated than on the baseline fMRI, the temporal lobes were less active than on the baseline fMRI, and the left middle frontal gyrus and right inferior frontal gyrus (both gyri are part of the frontal lobe) were more activated than on the baseline fMRI.

They additionally noted that the more subjectively sleepy a person felt, the more activated was his prefrontal cortex. They suspect that this may be due to the effect of adenosine (a component of ribonucleic acid). Adenosine plays a role in energy regulation. The level of adenosine continues to rise the longer a person remains awake. Drummond and associates5 believe that the higher-than-normal activation of the prefrontal cortex during the verbal tasks is the attempt of a sleep-deprived brain to counteract adenosine-induced sleepiness.

They also found that some subjects performed a free recall verbal task better than other subjects after the sleep-deprivation period. A comparison of the brain scans revealed that the sleep-deprived subjects who had better recall had a greater activation of their parietal lobes. Drummond and associates believe that areas normally not activated in the parietal lobes during a rested state may become temporarily activated during sleep deprivation to help a person maintain certain aspects of memory—in this case, working memory (memory used in the processes of learning, reasoning, and comprehension).

Heightened Awareness

This shifting of activity in brain regions may contribute to heightened awareness during sleep deprivation. Normally, the parietal lobes reduce their activity with sleep deprivation. These lobes play a role in one’s sense of self and spatial processing. Decreased activation of the lobes during sleep deprivation may in turn result in a decreased sense of self. With less of a sense of self, a person could sense that they are floating, have a sense of oneness with their surroundings, or have an experience with a higher power.

Although sleep deprivation can result in a depressed mood, it can ironically alleviate symptoms of depression temporarily in some depressed people, who are called “responders.” Brain imaging studies on depressed “responders” show that they have higher activity than depressed “nonresponders” in the cingulate gyri and the amygdala. Both structures are part of the limbic system. The cingulate gyri (which lie above the corpus callosum) play a role in emotion and transient mood changes, and the amygdala (which lies in the tip of the temporal lobe) plays a role in one’s sense of danger and doom. In “responders,” sleep deprivation reduces the activity of these areas to the levels found in nondepressed people. Scientists believe it is this reduction that alleviates depression.

Brain Imaging Techniques

In recent years, brain imaging techniques such as positron emission tomography (PET) and MRI have allowed scientists to directly and unobtrusively see what happens to the brain before, during, and after a period of sleep deprivation. This new look is prompting scientists to develop new views about sleep deprivation. Rather than seeing sleep deprivation as a thing to be avoided at all cost, scientists now see that alertness, productivity, and even creativity are possible on a severely restricted sleep schedule (polyphasic sleep). Rather than seeing everyone as “fatigue-vulnerable,” scientists now know some people can naturally withstand the effects of sleep deprivation for longer periods of time than normal. Rather than seeing a sleep-deprived brain as having one neurological “look” (decreased activation of the prefrontal cortex), scientists now see that a sleep-deprived brain, by shifting its activation, can be dynamic in its ability to allow a person to perform needed activities. With changing views and new findings, scientists hope to use sleep deprivation to improve health and safety. For example, more investigations into depressed “responders” could prove helpful in the diagnosis or treatment of depression and other brain disorders; more experiments on polyphasic sleep may reveal how it can be effectively used in place of stimulant drugs now used to maintain alertness for long periods; and more studies that can precisely determine an individual’s fatigue-vulnerability or fatigue-resistance before performing activities requiring long periods of alertness could help reduce accidents.

Regina Patrick, RPSGT, is a contributing writer for Sleep Review.

References
1. Caldwell JA, Smith JK, Caldwell JL, et al. United States Air Force Research Lab, Human Effectiveness Directorate. Functional magnetic resonance imaging shows potential for predicting individual differences in fatigue vulnerability. Brooks City, Tex: Office of Public Affairs; 2004.
2. Stampi C. What you can do about sleep deprivation: lessons from around-the-world solo sailors. Available at: http://globalrph.healthology.com/globalrph/14912.htm. Accessed March 5, 2005.
3. Dinges DF, van Dongen HPA, Maislin G, et al. Countermeasures to neurobehavioral deficits from cumulative partial sleep deprivation during space flight. Available at: http://peer1.nasaprs.com/cfpro/
peer_review/ltb1_00.cfm?id=129. Accessed March 5, 2005.
4. Famous four hour sleepers. Available at: http://answers.google.com/answers/
threadview?id=2001. Accessed July 27, 2005.
5. Drummond SP, Brown, GG, Gillin JC, et al. Altered brain response to verbal learning following sleep deprivation. Nature. 2000;403:655-657.