Sleep deprivation affects people differently — both mentally and at the molecular level — which may help doctors predict who will suffer most from all-nighters, reports Healthline.

Are you one of those people who can pull an all-nighter and give the best presentation of your life at work the next day? Or does missing just a few hours of sleep turn you into an incoherent zombie with a super-craving for triple shots of espresso?

It’s not a myth that some people “have it” when it comes to functioning on low sleep. Research shows that lack of sleep affects people differently — both mentally and at the molecular level. Researchers are using this natural variation to find biomarkers that can help identify people most at risk of the negative effects of not getting enough sleep.